Frictional properties of interfaces with dynamic chemical bonds have been the subject of intensive experimental investigation and modeling, as it provides important insights into the molecular origin of the empirical rate and state laws, which have been highly successful in describing friction from nano to geophysical scales. Using previously developed theoretical approaches requires time-consuming simulations that are impractical for many realistic tribological systems. To solve this problem and set a framework for understanding microscopic mechanisms of friction at interfaces including multiple microscopic contacts, we developed an analytical approach for description of friction mediated by dynamical formation and rupture of microscopic interfacial contacts, which allows to calculate frictional properties on the time and length scales that are relevant to tribological experimental conditions. The model accounts for the presence of various types of contacts at the frictional interface and predicts novel dependencies of friction on sliding velocity, temperature and normal load, which are amenable to experimental observations. Our model predicts the velocity-temperature scaling, which relies on the interplay between the effects of shear and temperature on the rupture of interfacial contacts. The proposed scaling can be used to extrapolate the simulation results to a range of very low sliding velocities used in nanoscale friction experiments, which is still unreachable by simulations. For interfaces including two types of interfacial contacts with distinct properties, our model predicts novel double-peaked dependencies of friction on temperature and velocity. Considering friction force microscopy experiments (FFM), we found that the non-uniform distribution of normal load across the interface leads to a distribution of barrier heights for contact formation. The results obtained in this case allowed to reveal a mechanism of nonlinear dependence of friction on normal load observed in recent FFM experiments and predict the effect of normal load on velocity and temperature dependencies of friction. Our work provides a promising avenue for the interpretation of the experimental data on friction at interfaces including microscopic contacts and opens new pathways for the rational control of the frictional response. (C) 2020 Elsevier Ltd. All rights reserved.