Piezoelectric and triboelectric nanogenerators have been widely studied in the past years for their advantages of easy design/manufacturing, small size, and flexibility. Nanogenerators that are developed based on the coupled piezoelectric and triboelectric effects (PTCNG) can make full use of the mechanical energies and achieve both higher output and sensing performance. This review aims to cover the recent research progress of PTCNG by presenting in detail their key technologies in terms of operating principles, integration concept, and performance enhancement strategies, with a focus on their structural simplification and efficiency performance improvement. The latest applications of PTCNG in tactile sensors and energy-harvesting system are also illustrated. Finally, we discuss the main challenges and prospects for the future development of PTCNG, hoping that this work can provide a new insight into the development of all-in-one mechanical energy-scavenging and sensing devices.