Introductionof lubricant phase into thermally sprayed coating while avoids high-temperature ablation is still a challenge. Here, vacuum impregnation and hydrothermal reaction, acted as a post-treatment process, was applied to synthesize MoS2 phase on and within high-entropy alloy (HEA) coating. The as-synthesized MoS2 phase with high purity and spherical shape distributed in the pores and finally formed a thin layer on coating surface. Compared to the single HEA coating, coefficient of friction (COF) and wear rate (Q) of the HEA/MoS2 composite coatings possessed a significantly reduction, i.e 87.2% and 75.6% reduction in COF and Q at 2 N, respectively. Besides, owing to the formation of lubricating film during the sliding process, the composite coating had a more stable sliding process. At the same time, the doped MoS2 played a positive role in reducing abrasive- and adhesive wears for both coating and coupling ball. Since the lubricating film can be continuously replenished and repaired, the HEA/MoS2 self-lubricating coatings maintained a good chemical stability and provided a relatively good wear properties.