It is of significance to develop high-performance organic/inorganic hybrid thermoelectric (TE) materials for flexible cross-plane TE devices. In this work, we synthesize a flexible and free-standing sandwich-like TE film by depositing Bi2Te3 nanocrystals among conducting porous PEDOT nanowire scaffold. The mechanically robust Bi2Te3@PEDOT nanowire film exhibits record Seebeck coefficient of 266.4 µV K-1 with corresponding power factor of 740.2 µW m-1 K-2 and a zT value of 0.27 at room temperature. Afterwards, we build new types of wearable cross-plane TE generator (TEG) and TE-powered temperature sensor array with reduced number of electric leads in comparison to traditional designs. The TEG shows a maximum power density of 3.48 µW cm-2 at a temperature difference of 17.8 K, (predicted out power density of 70.6 µW cm-2 at ΔT = 80 K), outperforming most of organic and organic/inorganic based ones. The conformal TE-powered temperature sensor array exhibits high and stable thermal sensitivity with a resolution of 0.05 K.