This study focuses on the relationship between meniscectomy and osteochondral junction health, and their integrity on cartilage lubrication. Using a previously published multi-component joint computational model, we explored the impact of increasing degree of meniscectomy and osteochondral flow conductivity on joint lubrication. Results suggest a greater effect of meniscectomy on joint lubrication when the osteochondral junction is healthy. However, the impact is less pronounced when the osteochondral junction is already diseased due to compromised lubrication capability. This research provides a first-time quantitative analysis of this interaction, which highlights the importance of adequately evaluating the osteochondral junction’s condition before meniscectomy surgery. It also suggests that reducing post-surgery activity level may be beneficial for patients with diseased junctions undergoing meniscectomy.