This study aims to investigate the application and machining characteristics of brittle conductive ceramics using ultrasonic vibration-assisted powder-mixed electrical discharge machining (UV-PMEDM) technology. Titanium nitride (TiN) ceramics are widely used in aerospace, biomedicine, and electronics due to their excellent properties. However, the conventional mechanical machining methods of these materials result in severe tool wear, high costs, and low efficiency. Although electrical discharge machining (EDM) can overcome some limitations, it typically exhibits a low material removal rate and poor surface quality. This study utilizes the UV-PMEDM technology to process TiN ceramics. Single-factor experiments are conducted to analyze the effects of processing parameters, including ultrasonic amplitude, powder concentration, pulse-on time, and pulse-off time, on the material removal rate, surface roughness, and relative electrode wear rate, which indicate the EDM processing performance. With the assistance of ultrasonic vibration and mixed powders, the material removal rate of TiN ceramics using UV-PMEDM reaches 0.50 mm3/min, while maintaining a relative electrode wear rate below 1 % and surface roughness lower than 4.2 μm. The synergistic combination of ultrasonic vibration and mixed powders significantly enhances the processing efficiency and reduces surface roughness of TiN ceramics. These findings contribute to a better understanding of machining strategies for brittle conductive ceramics.