Hypervalent Iodine(III)-Mediated Benzannulation of Enamines with Alkynes: an Efficient Synthesis of Substituted Aminonaphthoic Acid Derivatives

An intermolecular two CC bond formation procedure for the synthesis of carbocycles mediated by hypervalent iodine(III) reagents was developed. This metal free protocol provided a new approach for the synthesis of useful substituted 1-amino-2-naphthoic acid derivatives via benzannulation reactions. Various N-unsubstituted and N-alkyl substituted aromatic enamines with terminal alkynes and non-terminal alkynes can be converted into corresponding 1-amino-2-naphthoic acid derivatives under mild reaction conditions. When meta-substituted phenyl enamines were employed in the reaction, two cyclization paths were detected in the reaction and ortho-cyclization products were the only or major products. Good functional group tolerance, readily available material and high atom utilization efficiency make this method a potential procedure which may find broad application in organic synthesis.

成果名称:低表面能涂层

合作方式:技术开发

联 系 人:周老师

联系电话:13321314106

成果名称:低表面能涂层

合作方式:技术开发

联 系 人:周老师

联系电话:13321314106

成果名称:低表面能涂层

合作方式:技术开发

联 系 人:周老师

联系电话:13321314106

成果名称:低表面能涂层

合作方式:技术开发

联 系 人:周老师

联系电话:13321314106

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