Hydrogel electrode interfaces have shown tremendous promise in the acquisition of surface electromyography (EMG) signals. However, the perspiration or moisture environments will trigger the deadhesion between hydrogel electrodes and human skin. Despite the hydrophobic/hydrophilic surfaces can perform the anti-moisture or adhesion respectively, it remains a challenge to integrally form a Janus hydrogel with homogeneous mechanical elasticity and electronic performance. Herein, a surface induction strategy is proposed to approach the hydrophobic/hydrophilic hydrogel surfaces. The hydrophobic interaction between surfactants and molds regulates the distribution of hydrophobic/hydrophilic monomers on the surface. The hydrophobic molds induce a hydrophilic hydrogel surface, while the hydrophilic molds induce a hydrophobic surface. It presents a new phenomenon of reversal wettability inducing and optional hydrogel surfaces. The integral Janus hydrogel can be easily obtained by the hydrophilic molds. Balance of adhesion, elasticity, and conductivity endows the hydrogel electrode patch with durable conformal adhesion and high-fidelity EMG signals even in the sweaty epidermis due to the asymmetric wettability surfaces. This hydrogel performs the quantitative description of muscle strength and accurate fatigue assessment. It offers a reliable candidate for future practical applications in continuous digital healthcare and intelligent human–machine interaction, even the Metaverse.