Grease lubrication is cost-effective and low-maintenance for motorized spindles, but standard steel bearings can fail at high speeds. This study focuses on high-speed full ceramic ball bearings lubricated with grease. The coefficient of friction torque in the empirical formula is corrected by establishing the heat generation model of full ceramic ball bearing and combining it with experiments. A simulation model of grease flow is established to study the influence of grease filling amount on grease distribution. The simulation model of the temperature field of a full ceramic ball bearing is established to analyze the influence of rotating speed on bearing heat generation, and experiments verify the calculation results of the theoretical model. The results show that an optimal grease filling amount of 15~25% ensures even distribution without accumulation. Additionally, when the amount of grease is constant, the outer ring temperature increases with higher rotating speeds. The test results show that when the grease filling is 0.9~1.2 g, it accounts for about 9~12% of the volume of the bearing cavity, and the temperature of the outer ring is the lowest. At a rotation speed of 24,000 rpm, the outer ring temperature of the grease-lubricated bearing is 50.1 °C, indicating a reasonable range for use in motorized spindles. It provides a theoretical basis for the optimization design of macro-structural parameters of full ceramic ball bearings in the future, which can minimize heat generation and maximize bearing capacity.