In a gear transmission, power losses come from a variety of sources, classified as load-dependent and no-load-dependent losses. No-load-dependent losses are the ones that remain constant regardless of the applied load, such as losses due to drag in rolling element bearings, seals, churning and/or windage for gears. Load-dependent losses include friction losses due to sliding and rolling between gear teeth. These losses are particularly important in some gear transmissions because of their direct impact on overall efficiency and thermal behaviour. Consequently, knowledge of the friction coefficient associated to this loss is of major interest for optimising gears (geometry, surface finish, lubrication, etc.). In this article, a new method is proposed for predicting the mechanical efficiency losses associated with the mean coefficient of friction for pairs of cylindrical gears. It is based on a model developed previously to estimate the instantaneous tooth friction along the plane of action in gears. This model takes into account the lubricant shear and the friction on contacting asperities. The proposed mean friction coefficient is deduced from the instantaneous friction coefficient using specific calculations, particularly at the pitch point. To verify the method, the estimated results are compared with those in the literature calculated for gears and operating conditions common on FZG test rigs.