The integration of diverse weaving angles in vascular stent design proves beneficial for addressing complex applications such as bending, branching, and load-bearing. However, the weaving process may introduce frictional corrosion issues among threads, necessitating further investigation into frictional behaviors at different weaving angles. This study simplifies the contact between nickel-titanium (NiTi) alloy threads in woven stents as line-to-line contact between rods. A proposed in vitro experiment, based on weaving angles of 30°, 45°, 60°, 75°, and 90°, systematically analyzes friction and wear characteristics, including friction coefficients, wear parameters, and morphology. Findings indicate significant impacts of weaving angles on tribological behaviors, with 30° weaving angle stents exhibiting the lowest wear rate. The study identifies four developmental stages in the life cycle of line-to-line contact wear: breaking-in wear, steady wear, severe wear, and post-stable wear. Under 25% calf serum lubrication, lower friction coefficients and wear rates are observed, validating NiTi alloy suitability for lubricated human environments. The investigation reveals a non-linear correlation between weaving angles, friction cycles, and wear rates, offering insights for the tribological design of woven instruments.