Flexible and stretchable electrodes are crucial components for wearable electronic devices. Herein, a serpentine liquid electrode based dual-mode skin sensors (SLEDSS) that leverages a highly deformable and serpentine liquid electrode is developed. The functional carboxylated multi-walled carbon nanotubes / Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (MWCNT-COOH / PEDOT: PSS) network structure endows the SLEDSS with a stable linear change in resistance. Additionally, a solid–liquid double electric layer generated between the solid surface and liquid electrode facilitates a higher triboelectric output performance. As a result, the SLEDSS features dual-modal sensing capabilities, including both resistive and triboelectric modes. The flowability of the liquid electrode enables it to fully adapt to different types of deformation, thereby allowing SLEDSS to effectively collect energy in different forms of movement, such as tapping, stretching, bending, twisting, and unpredictable transformations based on practical applications. SLEDSS can maintain its performance even at up to 550.32% strain, displaying a monotonically increasing relationship between the stretchable length and open-circuit voltage. Finally, the SLEDSS is applied as a wearable power source and self-powered sensor for monitoring biomechanical movements, the excellent stretchable performance and ultra-high sensitivity to mechanical stimulation provided by the SLEDSS offer new prospects for self-powered sensors.